Chemotherapy pyroptosis
WebMay 24, 2024 · Pyroptosis is a form of programmed necrotic cell death that provokes robust immune response and releases pro-inflammatory cytokines [].Gasdermin (GSDM) is the direct executioner of pyroptosis [2,3,4]. WebMay 1, 2024 · It is shown that GSDME, which was originally identified as DFNA5 (deafness, autosomal dominant 5), can switch caspase-3-mediated apoptosis induced by TNF or chemotherapy drugs to pyroptosis, …
Chemotherapy pyroptosis
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WebUp to now, there many researches revealed that cancer cells can die of pyroptosis such as esophageal carcinoma, breast cancer, ovarian cancer, lung cancer and colon cancer 10,19–21 and studies also indicated that chemotherapy drugs and other reagents can trigger pyroptosis in various cancer. 22 But whether pyroptosis is involved in … WebSep 27, 2024 · Pyroptosis is a lytic and inflammatory form of programmed cell death and could be induced by chemotherapy drugs via caspase-3 mediation. However, the key …
WebSep 1, 2024 · For quite a long time, necrosis was considered a chaotic and unorganized form of cell death. However, studies conducted during the past few decades unveiled multiple types of programmed necrosis, such as necroptosis, pyroptosis and ferroptosis. These types of programmed necrosis have been shown to play crucial roles in mediating … WebApr 24, 2024 · Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the …
WebApr 24, 2024 · Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-dependent mitochondrial pathway. BAK/BAX activation causes the … WebFeb 21, 2024 · Furthermore, the synergistic therapy of SDT and chemotherapy could induce pyroptosis of gastric cancer cells and play anti-tumor effects in vivo and in vitro. …
WebAug 8, 2024 · In summary, we found that all chemotherapy drugs may lead to pyroptosis and GSDME cleavage in breast cancer cells. Also, DOX had the strongest ability to induce pyroptosis and the utmost GSDME cleavage among all drugs. Thus, the GSDME should be considered as the major regulator of pyroptosis-induced cell death. 13.
WebPyroptosis induction also plays a dual role in antitumor immunotherapy: on the one hand, it suppresses antitumor immunity by promoting the release of inflammatory factors, and on the other hand, it inhibits tumor cell proliferation by triggering antitumor inflammatory responses. In addition, cell scorching plays an essential role in chemotherapy. mohap hospitalsWebApr 13, 2024 · Developing a pyroptosis-related gene signature to better predict the prognosis and immune status of patients with head and neck squamous cell carcinoma ... The combination of immunotherapy chemotherapy radiotherapy and targeted medical help inhibit tumor progression through synergistic mechanisms and improve Frontiers in … moh approved clinic listWebAug 8, 2024 · In summary, we found that all chemotherapy drugs may lead to pyroptosis and GSDME cleavage in breast cancer cells. Also, DOX had the strongest ability to … moh approved clinic for swab testWebPyroptosis is an inflammatory type of cell death closely related to ... Gao W, Shi X, Ding J, Liu W, He H, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin ... moh approved art clinicsWebMar 29, 2024 · Wang et al. and Rogers et al. found that chemotherapy drugs induced the activation of caspase-3 in tumor cells with high GSDME expression and induced pyroptosis. 16,17 In tumor cell lines with low ... mohap medicalWebNov 14, 2024 · Cancer is a complex pathological disease and the existing strategies for introducing chemotherapeutic agents have restricted potential due to a lack of cancer cell targeting specificity, cytotoxicity, … moh applicationsWebFeb 26, 2024 · Pyroptosis associated proteins such as caspase-1, GSDMD were low expressed in multiple cell types. Therefore, inducing pyroptosis in tumor cells has been a new strategy of cancer treatment. In recent years, various chemotherapy drugs, natural compounds and synthetic medicines were found to induce pyroptosis in different types … moh-apps/home