Ctgf tumor

Author: gazo

August undefined, 2024

WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly expressed.

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WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth … WebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. ... CCN2 inhibits lung cancer … belden19364電源ケーブル

The reactive tumor microenvironment: MUC1 signaling directly

WebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are … WebElevated CTGF expression has been detected in many tumor types [5,17] where it has been identified as an invasion-specific gene [18] and is highly expressed within the neoplastic epithelium of PDAC [9]. Wenger et al. showed 59-fold enhancement of CTGF expression in 15 out of 19 samples of pancreatic tumors, compared with only 4.5-fold WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary … belc チラシ

Targeting of CCN2 suppresses tumor progression and improves …

Connective tissue growth factor in tumor pathogenesis

WebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. WebFeb 28, 2024 · Results . AuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. belcy マガジンWebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. belcomo ランチ

"WebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … " - Ctgf tumor

Ctgf tumor

Molecular tracking of insulin resistance and inflammation …

WebSep 12, 2024 · INTRODUCTION. Urothelial bladder cancer (UBC) is a common urinary malignancy. In 2012, about 429,800 new cases and 165,100 deaths arising from UBC occur worldwide [].In the United States, UBC is estimated that to be the second most frequent genitourinary tract cancer and the fourth most common cancer in male in 2024 [].At … WebJun 3, 2013 · Background The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). Experimental design CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The …

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WebOct 29, 2024 · Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple … WebMar 31, 2011 · These studies suggest that Cyr61 and CTGF are 2 critical TAZ transcriptional targets mediating TAZ-induced drug resistance in breast cancer cells. Together, our studies provided the first biological evidence that overexpression of the TAZ oncogene can cause drug resistance of breast cancer cells through direct activation of 2 secreted and ...

WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … WebApr 20, 2016 · Breast cancer is the most common cancer in women worldwide, and approximately 90% of breast cancer deaths are the result of metastasis. Metastasis is the process by which tumor cells detach from a primary tumor and migrate to nearby blood vessels or the lymph system, and are thereby able to spread to other organs in the host …

WebCTGF expression has been tied in with tumor growth, invasion, and metastasis. It shows aberrant expression in many forms of cancer, such as prostate, breast, and esophageal … WebMar 1, 2015 · Upon TGFβ1 stimulation, low-CTGF HCC cells formed tumors with a high stromal content and CTGF expression, which was inhibited by treatment with LY2109761. Blocking TGFβ signaling with LY2109761 or galunisertib inhibited CTGF synthesis and release by HCC cells and reduced tumor stromal content by inhibiting fibroblastic cell …

WebJun 1, 2024 · Increasing evidence indicates that connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and metastasis by regulating cell proliferation, migration, invasion, drug resistance, and epithelial–mesenchymal transition (EMT). CTGF is also involved in the tumor …

WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM … belc チラシ森永橋店WebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly … 厚揚げ炒め物WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary carcinomas, 6 spongioblastoma, 3 thyroid cancers, 7 and CRC. 8 Taking into account that CTGF performs a significant role in tumor metastasis and that metastatic cancerous ... bel cuore サドルバッグ bel corpo フィットネスWebApr 7, 2024 · Recently, CTGF was also found to play an important role in the growth of bone metastases from prostate and breast cancer through forming CTGF–Runx2–RANKL axis 37. bel boxカフェテリアWebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … belden 19364 非メッキ電源ケーブルWebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ... belden 19364 電源ケーブル音質