WebData generated over the past 17 years clearly indicate that glycosylation changes may significantly alter the biological activity and thus the overall role of a glycoconjugate in relation to the molecular mechanism of disease, for example, IgG and IgA1 agalactosylation in rheumatoid arthritis (RA) and IgA nephropathy/sLe x expression in various ... WebAs glycans play a key role in many biological processes and are involved in most known diseases, I am excited to share our new review article highlighting the…
Glycosylation in health and disease Nature Reviews Nephrology
WebGlycobiology of rheumatic diseases. Kissel T et al. Nature Reviews. Rheumatology. 2024 Nov 23; ... In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes and disease progression. For example, the Fc-glycan composition on (auto)antibodies is associated with disease activity, and the ... WebGlycobiology of the Rheumatic Diseases: An Update 273 Glycosylation alters the structure of the IgG molecule with functional sequelae (Jefferis and Lund, 2002; Wright et al., 2000; Wright and Morrison, 1993); the ability of IgG3 to trigger cell-lysis through its interaction with human killer cells is eliminated by newest nuclear reactor
Glycobiology of rheumatic diseases Request PDF - ResearchGate
WebGlycobiology of rheumatic diseases ... Fc domain glycosylation of (auto)antibodies in rheumatic diseases. IgG,secretedbyclass-switchedBcells,isahighlyabundantglyco - WebDec 19, 2024 · Glycosylation has a profound influence on protein activity and cell biology through a variety of mechanisms, such as protein stability, receptor interactions and signal transduction. In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes... WebGlycobiology of rheumatic diseases. Nat Rev Rheumatol. 2024; 19(1) ... In many rheumatic diseases, a shift in protein glycosylation occurs, and is associated with inflammatory processes and disease progression. For example, the Fc-glycan composition on (auto)antibodies is associated with disease activity, and the presence of additional … newest nuclear submarine